Publications
2016
Toia F, Buccheri S, Anfosso A, Moschella F, Dieli F, Meraviglia S, Cordova A.
Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact
on Clinical Outcome. PLoS One. 2016 Feb 25;11(2):e0149570. doi:
10.1371/journal.pone.0149570. eCollection 2016. PubMed PMID: 26915072; PubMed
Central PMCID: PMC4767817.
Ciccia F, Guggino G, Ferrante A, Raimondo S, Bignone R, Rodolico V, Peralta S,
Van Tok M, Cannizzaro A, Schinocca C, Ruscitti P, Cipriani P, Giacomelli R,
Alessandro R, Dieli F, Rizzo A, Baeten D, Triolo G. IL-9 over-expression and Th9
polarization characterize the inflamed gut, the synovial tissue and the
peripheral blood of patients with psoriatic arthritis. Arthritis Rheumatol. 2016
Feb 19. doi: 10.1002/art.39649. [Epub ahead of print] PubMed PMID: 26895441.
Caccamo N, Dieli F. Inflammation and the coagulation system in tuberculosis:
Tissue Factor leads the dance. Eur J Immunol. 2016 Feb;46(2):303-6. doi:
10.1002/eji.201546225. PubMed PMID: 26763085.
Marcucci F, Stassi G, De Maria R. Epithelial-mesenchymal transition: a new
target in anticancer drug discovery. Nat Rev Drug Discov. 2016 Jan 29. doi:
10.1038/nrd.2015.13. [Epub ahead of print] PubMed PMID: 26822829.
De Angelis ML, Zeuner A, Policicchio E, Russo G, Bruselles A, Signore M,
Vitale S, De Luca G, Pilozzi E, Boe A, Stassi G, Ricci-Vitiani L, Amoreo CA,
Pagliuca A, Francescangeli F, Tartaglia M, De Maria R, Baiocchi M. Cancer Stem
Cell-Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy
Resistance. Stem Cells Transl Med. 2016 Apr;5(4):511-23. doi:
10.5966/sctm.2015-0214. Epub 2016 Mar 8. PubMed PMID: 26956206.
Catalano V, Dentice M, Ambrosio R, Luongo C, Carollo R, Benfante A, Todaro M,
Stassi G, Salvatore D. Activated Thyroid Hormone Promotes Differentiation and
Chemotherapeutic Sensitization of Colorectal Cancer Stem Cells by Regulating Wnt
and BMP4 Signaling. Cancer Res. 2016 Mar 1;76(5):1237-44. doi:
10.1158/0008-5472.CAN-15-1542. Epub 2015 Dec 16. PubMed PMID: 26676745.
Di Rocco G, Verdina A, Gatti V, Virdia I, Toietta G, Todaro M, Stassi G, Soddu
S. Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target
effects rather than prevalence of HIPK2-Δe8 isoform. Oncotarget. 2016 Jan
12;7(2):1675-86. doi: 10.18632/oncotarget.6423. PubMed PMID: 26625198.
Zane M, Scavo E, Catalano V, Bonanno M, Todaro M, De Maria R, Stassi G. Normal
vs cancer thyroid stem cells: the road to transformation. Oncogene. 2016 Feb
18;35(7):805-15. doi: 10.1038/onc.2015.138. Epub 2015 May 11. Review. PubMed
PMID: 25961919.
2015
Meraviglia S, Lo Presti E, Dieli F, Stassi G. γδ T cell-based anticancer
immunotherapy: progress and possibilities. Immunotherapy. 2015;7(9):949-51. doi:
10.2217/imt.15.68. Epub 2015 Aug 27. PubMed PMID: 26569071.
Smith SG, Smits K, Joosten SA, van Meijgaarden KE, Satti I, Fletcher HA,
Caccamo N, Dieli F, Mascart F, McShane H, Dockrell HM, Ottenhoff TH; TBVI TB
Biomarker Working Group. Intracellular Cytokine Staining and Flow Cytometry:
Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.
PLoS One. 2015 Sep 14;10(9):e0138042. doi: 10.1371/journal.pone.0138042.
eCollection 2015. PubMed PMID: 26367374; PubMed Central PMCID: PMC4569436.
Ciccia F, Guggino G, Rizzo A, Manzo A, Vitolo B, La Manna MP, Giardina G,
Sireci G, Dieli F, Montecucco CM, Alessandro R, Triolo G. Potential involvement
of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis. Rheumatology
(Oxford). 2015 Dec;54(12):2264-72. doi: 10.1093/rheumatology/kev252. Epub 2015
Jul 15. PubMed PMID: 26178600.
van Meijgaarden KE, Haks MC, Caccamo N, Dieli F, Ottenhoff TH, Joosten SA.
Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb)
presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory
phenotype and represent a novel human T-cell subset. PLoS Pathog. 2015 Mar
24;11(3):e1004671. doi: 10.1371/journal.ppat.1004671. eCollection 2015 Mar.
PubMed PMID: 25803478;
Caccamo N, Pietra G, Sullivan LC, Brooks AG, Prezzemolo T, La Manna MP, Di
Liberto D, Joosten SA, van Meijgaarden KE, Di Carlo P, Titone L, Moretta L,
Mingari MC, Ottenhoff TH, Dieli F. Human CD8 T lymphocytes recognize
Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis
and express type 2 cytokines. Eur J Immunol. 2015 Apr;45(4):1069-81. doi:
10.1002/eji.201445193. Epub 2015 Feb 17. PubMed PMID: 25631937.
Francescangeli F, Contavalli P, De Angelis ML, Baiocchi M, Gambara G, Pagliuca
A, Fiorenzano A, Prezioso C, Boe A, Todaro M, Stassi G, Castro NP, Watanabe K,
Salomon DS, De Maria R, Minchiotti G, Zeuner A. Dynamic regulation of the cancer
stem cell compartment by Cripto-1 in colorectal cancer. Cell Death Differ. 2015
Oct;22(10):1700-13. doi: 10.1038/cdd.2015.19. Epub 2015 Mar 20. PubMed PMID:
26343543; PubMed Central PMCID: PMC4563784.
De Cola A, Volpe S, Budani MC, Ferracin M, Lattanzio R, Turdo A, D'Agostino D,
Capone E, Stassi G, Todaro M, Di Ilio C, Sala G, Piantelli M, Negrini M, Veronese
A, De Laurenzi V. miR-205-5p-mediated downregulation of ErbB/HER receptors in
breast cancer stem cells results in targeted therapy resistance. Cell Death Dis.
2015 Jul 16;6:e1823. doi: 10.1038/cddis.2015.192. PubMed PMID: 26181203; PubMed
Central PMCID: PMC4650737.
Tirinato L, Liberale C, Di Franco S, Candeloro P, Benfante A, La Rocca R,
Potze L, Marotta R, Ruffilli R, Rajamanickam VP, Malerba M, De Angelis F, Falqui
A, Carbone E, Todaro M, Medema JP, Stassi G, Di Fabrizio E. Lipid droplets: a new
player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem
Cells. 2015 Jan;33(1):35-44. doi: 10.1002/stem.1837. PubMed PMID: 25186497;
PubMed Central PMCID: PMC4311668.
2014
Guggino G, Scottà C, Lombardi G, Dieli F, Sireci G. Invariant natural killer T
cells treated with rapamycin or transforming growth factor-β acquire a regulatory
function and suppress T effector lymphocytes. Cell Mol Immunol. 2014 Apr 6. doi:
10.1038/cmi.2015.20. [Epub ahead of print] PubMed PMID: 25849118.
Lo Presti E, Dieli F, Meraviglia S. Tumor-Infiltrating γδ T Lymphocytes:
Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor
Microenvironment. Front Immunol. 2014 Nov 24;5:607. doi:
10.3389/fimmu.2014.00607. eCollection 2014. Review. PubMed PMID: 25505472; PubMed
Central PMCID: PMC4241840.
Dieli F, Mavilio D. Editorial: activation, functions, and generation of
immunological memory in γδ T lymphocytes: lessons from nonhuman primates. J
Leukoc Biol. 2014 Dec;96(6):948-50. doi: 10.1189/jlb.4CE0714-364R. PubMed PMID:
25452618.
Prezzemolo T, Guggino G, La Manna MP, Di Liberto D, Dieli F, Caccamo N.
Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium
tuberculosis. Front Immunol. 2014 Apr 22;5:180. doi: 10.3389/fimmu.2014.00180.
eCollection 2014. Review. PubMed PMID: 24795723; PubMed Central PMCID:
PMC4001014.
Zeuner A, Todaro M, Stassi G, De Maria R. Colorectal cancer stem cells: from
the crypt to the clinic. Cell Stem Cell. 2014 Dec 4;15(6):692-705. doi:
10.1016/j.stem.2014.11.012. Review. PubMed PMID: 25479747.
Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo
T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G.
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving
colon cancer metastasis. Cell Stem Cell. 2014 Mar 6;14(3):342-56. doi:
10.1016/j.stem.2014.01.009. PubMed PMID: 24607406.
Dieli F, Fadda R, Caccamo N. Butyrophilin 3A1 presents phosphoantigens to
human γδ T cells: the fourth model of antigen presentation in the immune system.
Cell Mol Immunol. 2014 Mar;11(2):123-5. doi: 10.1038/cmi.2013.54. Epub 2013 Nov
25. PubMed PMID: 24270471; PubMed Central PMCID: PMC4003376.
Di Franco S, Todaro M, Dieli F, Stassi G. Colorectal cancer defeating?
Challenge accepted! Mol Aspects Med. 2014 Oct;39:61-81. doi:
10.1016/j.mam.2013.07.001. Epub 2013 Aug 5. Review. PubMed PMID: 23927966.
Bartucci M, Dattilo R, Moriconi C, Pagliuca A, Mottolese M, Federici G,
Benedetto AD, Todaro M, Stassi G, Sperati F, Amabile MI, Pilozzi E, Patrizii M,
Biffoni M, Maugeri-Saccà M, Piccolo S, De Maria R. TAZ is required for metastatic
activity and chemoresistance of breast cancer stem cells. Oncogene. 2015 Feb
5;34(6):681-90. doi: 10.1038/onc.2014.5. Epub 2014 Feb 17. PubMed PMID: 24531710.
Volonté A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L,
Bissolati M, Ghirardelli L, Orsenigo E, Ferrone S, Doglioni C, Stassi G,
Dellabona P, Staudacher C, Parmiani G, Maccalli C. Cancer-initiating cells from
colorectal cancer patients escape from T cell-mediated immunosurveillance in
vitro through membrane-bound IL-4. J Immunol. 2014 Jan 1;192(1):523-32. doi:
10.4049/jimmunol.1301342. Epub 2013 Nov 25. PubMed PMID: 24277698.
2013
Todaro M, Meraviglia S, Caccamo N, Stassi G, Dieli F. Combining conventional
chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells.
Oncoimmunology. 2013 Sep 1;2(9):e25821. Epub 2013 Jul 29. PubMed PMID: 24244907;
PubMed Central PMCID: PMC3825724.
Chen HC, Dieli F, Eberl M. An unconventional TRAIL to cancer therapy. Eur J
Immunol. 2013 Dec;43(12):3159-62. doi: 10.1002/eji.201344105. Epub 2013 Nov 4.
PubMed PMID: 24136367.
Catalano V, Turdo A, Di Franco S, Dieli F, Todaro M, Stassi G. Tumor and its
microenvironment: a synergistic interplay. Semin Cancer Biol. 2013 Dec;23(6 Pt
B):522-32. doi: 10.1016/j.semcancer.2013.08.007. Epub 2013 Sep 4. Review. PubMed
PMID: 24012661.
Todaro M, Orlando V, Cicero G, Caccamo N, Meraviglia S, Stassi G, Dieli F.
Chemotherapy sensitizes colon cancer initiating cells to Vγ9Vδ2 T cell-mediated
cytotoxicity. PLoS One. 2013 Jun 6;8(6):e65145. doi:
10.1371/journal.pone.0065145. Print 2013. PubMed PMID: 23762301; PubMed Central
PMCID: PMC3675136.
Dieli F, Stassi G, Todaro M, Meraviglia S, Caccamo N, Cordova A.
Distribution, function and predictive value of tumor-infiltrating γδ T
lymphocytes. Oncoimmunology. 2013 Apr 1;2(4):e23434. PubMed PMID: 23734305;
PubMed Central PMCID: PMC3654575.
Tallerico R, Todaro M, Di Franco S, Maccalli C, Garofalo C, Sottile R,
Palmieri C, Tirinato L, Pangigadde PN, La Rocca R, Mandelboim O, Stassi G, Di
Fabrizio E, Parmiani G, Moretta A, Dieli F, Kärre K, Carbone E. Human NK cells
selective targeting of colon cancer-initiating cells: a role for natural
cytotoxicity receptors and MHC class I molecules. J Immunol. 2013 Mar
1;190(5):2381-90. doi: 10.4049/jimmunol.1201542. Epub 2013 Jan 23. PubMed PMID:
23345327.
Caccamo N, Todaro M, Sireci G, Meraviglia S, Stassi G, Dieli F. Mechanisms
underlying lineage commitment and plasticity of human γδ T cells. Cell Mol
Immunol. 2013 Jan;10(1):30-4. doi: 10.1038/cmi.2012.42. Epub 2012 Oct 22. Review.
PubMed PMID: 23085943; PubMed Central PMCID: PMC4003171.
Todaro M, Turdo A, Bartucci M, Iovino F, Dattilo R, Biffoni M, Stassi G,
Federici G, De Maria R, Zeuner A. Erythropoietin activates cell survival pathways
in breast cancer stem-like cells to protect them from chemotherapy. Cancer Res.
2013 Nov 1;73(21):6393-400. doi: 10.1158/0008-5472.CAN-13-0248. Epub 2013 Sep 5.
PubMed PMID: 24008319
2012
Cordova A, Toia F, La Mendola C, Orlando V, Meraviglia S, Rinaldi G, Todaro
M, Cicero G, Zichichi L, Donni PL, Caccamo N, Stassi G, Dieli F, Moschella F.
Characterization of human γδ T lymphocytes infiltrating primary malignant
melanomas. PLoS One. 2012;7(11):e49878. doi: 10.1371/journal.pone.0049878. Epub
2012 Nov 26. PubMed PMID: 23189169; PubMed Central PMCID: PMC3506540.
Greco E, Quintiliani G, Santucci MB, Serafino A, Ciccaglione AR, Marcantonio
C, Papi M, Maulucci G, Delogu G, Martino A, Goletti D, Sarmati L, Andreoni M,
Altieri A, Alma M, Caccamo N, Di Liberto D, De Spirito M, Savage ND, Nisini R,
Dieli F, Ottenhoff TH, Fraziano M. Janus-faced liposomes enhance antimicrobial
innate immune response in Mycobacterium tuberculosis infection. Proc Natl Acad
Sci U S A. 2012 May 22;109(21):E1360-8. doi: 10.1073/pnas.1200484109. Epub 2012
Apr 25. PubMed PMID: 22538807; PubMed Central PMCID: PMC3361443.
Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C,
Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A,
Schuurhuis GJ, Wöhrer S, Arock M, Zuber J, Cerny-Reiterer S, Johnsen HE, Andreeff
M, Eaves C. Cancer stem cell definitions and terminology: the devil is in the
details. Nat Rev Cancer. 2012 Nov;12(11):767-75. doi: 10.1038/nrc3368. Epub 2012
Oct 11. PubMed PMID: 23051844.
2011
Ciccia F, Guggino G, Rizzo A, Ferrante A, Raimondo S, Giardina A, Dieli F,
Campisi G, Alessandro R, Triolo G. Potential involvement of IL-22 and
IL-22-producing cells in the inflamed salivary glands of patients with Sjogren's
syndrome. Ann Rheum Dis. 2012 Feb;71(2):295-301. doi: 10.1136/ard.2011.154013.
Epub 2011 Oct 6. PubMed PMID: 21979002.
Taverna S, Flugy A, Saieva L, Kohn EC, Santoro A, Meraviglia S, De Leo G,
Alessandro R. Role of exosomes released by chronic myelogenous leukemia cells in
angiogenesis. Int J Cancer. 2012 May 1;130(9):2033-43. doi: 10.1002/ijc.26217.
Epub 2011 Aug 8. PubMed PMID: 21630268; PubMed Central PMCID: PMC3236253.
Caccamo N, La Mendola C, Orlando V, Meraviglia S, Todaro M, Stassi G, Sireci
G, Fournié JJ, Dieli F. Differentiation, phenotype, and function of
interleukin-17-producing human Vγ9Vδ2 T cells. Blood. 2011 Jul 7;118(1):129-38.
doi: 10.1182/blood-2011-01-331298. Epub 2011 Apr 19. PubMed PMID: 21505189.
Tang ST, van Meijgaarden KE, Caccamo N, Guggino G, Klein MR, van Weeren P,
Kazi F, Stryhn A, Zaigler A, Sahin U, Buus S, Dieli F, Lund O, Ottenhoff TH.
Genome-based in silico identification of new Mycobacterium tuberculosis antigens
activating polyfunctional CD8+ T cells in human tuberculosis. J Immunol. 2011 Jan
15;186(2):1068-80. doi: 10.4049/jimmunol.1002212. Epub 2010 Dec 17. PubMed PMID:
21169544.
Lombardo Y, Scopelliti A, Cammareri P, Todaro M, Iovino F, Ricci-Vitiani L,
Gulotta G, Dieli F, de Maria R, Stassi G. Bone morphogenetic protein 4 induces
differentiation of colorectal cancer stem cells and increases their response to
chemotherapy in mice. Gastroenterology. 2011 Jan;140(1):297-309. doi:
10.1053/j.gastro.2010.10.005. Epub 2010 Oct 14. PubMed PMID: 20951698.
2010
Todaro M, Iovino F, Eterno V, Cammareri P, Gambara G, Espina V, Gulotta G,
Dieli F, Giordano S, De Maria R, Stassi G. Tumorigenic and metastatic activity of
human thyroid cancer stem cells. Cancer Res. 2010 Nov 1;70(21):8874-85. doi:
10.1158/0008-5472.CAN-10-1994. Epub 2010 Oct 19. PubMed PMID: 20959469.
Caccamo N, Guggino G, Joosten SA, Gelsomino G, Di Carlo P, Titone L, Galati
D, Bocchino M, Matarese A, Salerno A, Sanduzzi A, Franken WP, Ottenhoff TH, Dieli
F. Multifunctional CD4(+) T cells correlate with active Mycobacterium
tuberculosis infection. Eur J Immunol. 2010 Aug;40(8):2211-20. doi:
10.1002/eji.201040455. PubMed PMID: 20540114.
Cammareri P, Scopelliti A, Todaro M, Eterno V, Francescangeli F, Moyer MP,
Agrusa A, Dieli F, Zeuner A, Stassi G. Aurora-a is essential for the tumorigenic
capacity and chemoresistance of colorectal cancer stem cells. Cancer Res. 2010
Jun 1;70(11):4655-65. doi: 10.1158/0008-5472.CAN-09-3953. Epub 2010 May 11.
PubMed PMID: 20460511.
D'Asaro M, La Mendola C, Di Liberto D, Orlando V, Todaro M, Spina M, Guggino
G, Meraviglia S, Caccamo N, Messina A, Salerno A, Di Raimondo F, Vigneri P,
Stassi G, Fourniè JJ, Dieli F. V gamma 9V delta 2 T lymphocytes efficiently
recognize and kill zoledronate-sensitized, imatinib-sensitive, and
imatinib-resistant chronic myelogenous leukemia cells. J Immunol. 2010 Mar
15;184(6):3260-8. doi: 10.4049/jimmunol.0903454. Epub 2010 Feb 12. PubMed PMID:
20154204.
Ricci-Vitiani L, Pallini R, Biffoni M, Todaro M, Invernici G, Cenci T, Maira
G, Parati EA, Stassi G, Larocca LM, De Maria R. Tumour vascularization via
endothelial differentiation of glioblastoma stem-like cells. Nature. 2010 Dec
9;468(7325):824-8. doi: 10.1038/nature09557. Epub 2010 Nov 21. Erratum in:
Nature. 2011 Sep 8;477(7363):238. Nature. 2011 Jan 20;469(7330):432. PubMed PMID:
21102434.
Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH,
Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K,
Richel DJ, Stassi G, Medema JP. Wnt activity defines colon cancer stem cells and
is regulated by the microenvironment. Nat Cell Biol. 2010 May;12(5):468-76. doi:
10.1038/ncb2048. Epub 2010 Apr 25. PubMed PMID: 20418870.
Kemper K, Sprick MR, de Bree M, Scopelliti A, Vermeulen L, Hoek M, Zeilstra
J, Pals ST, Mehmet H, Stassi G, Medema JP. The AC133 epitope, but not the CD133
protein, is lost upon cancer stem cell differentiation. Cancer Res. 2010 Jan
15;70(2):719-29. doi: 10.1158/0008-5472.CAN-09-1820. Epub 2010 Jan 12. PubMed
PMID: 20068153.
2009
Porta C, Rimoldi M, Raes G, Brys L, Ghezzi P, Di Liberto D, Dieli F,
Ghisletti S, Natoli G, De Baetselier P, Mantovani A, Sica A. Tolerance and M2
(alternative) macrophage polarization are related processes orchestrated by p50
nuclear factor kappaB. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14978-83.
doi: 10.1073/pnas.0809784106. Epub 2009 Aug 17. PubMed PMID: 19706447; PubMed
Central PMCID: PMC2736429.
Francipane MG, Eterno V, Spina V, Bini M, Scerrino G, Buscemi G, Gulotta G,
Todaro M, Dieli F, De Maria R, Stassi G. Suppressor of cytokine signaling 3
sensitizes anaplastic thyroid cancer to standard chemotherapy. Cancer Res. 2009
Aug 1;69(15):6141-8. doi: 10.1158/0008-5472.CAN-09-0994. Epub 2009 Jul 28. PubMed
PMID: 19638576.
Todaro M, D'Asaro M, Caccamo N, Iovino F, Francipane MG, Meraviglia S,
Orlando V, La Mendola C, Gulotta G, Salerno A, Dieli F, Stassi G. Efficient
killing of human colon cancer stem cells by gammadelta T lymphocytes. J Immunol.
2009 Jun 1;182(11):7287-96. doi: 10.4049/jimmunol.0804288. PubMed PMID: 19454726.
Caccamo N, Guggino G, Meraviglia S, Gelsomino G, Di Carlo P, Titone L,
Bocchino M, Galati D, Matarese A, Nouta J, Klein MR, Salerno A, Sanduzzi A, Dieli
F, Ottenhoff TH. Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in
patients with active tuberculosis and in individuals with latent infection. PLoS
One. 2009;4(5):e5528. doi: 10.1371/journal.pone.0005528. Epub 2009 May 13. PubMed
PMID: 19436760; PubMed Central PMCID: PMC2678250.
Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P,
Hur MH, Diebel ME, Monville F, Dutcher J, Brown M, Viens P, Xerri L, Bertucci F,
Stassi G, Dontu G, Birnbaum D, Wicha MS. Breast cancer cell lines contain
functional cancer stem cells with metastatic capacity and a distinct molecular
signature. Cancer Res. 2009 Feb 15;69(4):1302-13. doi:
10.1158/0008-5472.CAN-08-2741. Epub 2009 Feb 3. PubMed PMID: 19190339; PubMed
Central PMCID: PMC2819227.
2008
Di Liberto D, Locati M, Caccamo N, Vecchi A, Meraviglia S, Salerno A, Sireci
G, Nebuloni M, Caceres N, Cardona PJ, Dieli F, Mantovani A. Role of the chemokine
decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial
resistance in Mycobacterium tuberculosis infection. J Exp Med. 2008 Sep
1;205(9):2075-84. doi: 10.1084/jem.20070608. Epub 2008 Aug 11. PubMed PMID:
18695004; PubMed Central PMCID: PMC2526202.
Sireci G, La Manna MP, Di Liberto D, Lo Dico M, Taniguchi M, Dieli F, Salerno
A. Prophylaxis of lipopolysaccharide-induced shock by alpha-galactosylceramide. J
Leukoc Biol. 2008 Aug;84(2):550-60. doi: 10.1189/jlb.0707499. Epub 2008 May 5.
PubMed PMID: 18458153.
Pallini R, Ricci-Vitiani L, Banna GL, Signore M, Lombardi D, Todaro M, Stassi
G, Martini M, Maira G, Larocca LM, De Maria R. Cancer stem cell analysis and
clinical outcome in patients with glioblastoma multiforme. Clin Cancer Res. 2008
Dec 15;14(24):8205-12. doi: 10.1158/1078-0432.CCR-08-0644. PubMed PMID: 19088037.
Vermeulen L, Todaro M, de Sousa Mello F, Sprick MR, Kemper K, Perez Alea M,
Richel DJ, Stassi G, Medema JP. Single-cell cloning of colon cancer stem cells
reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci U S A. 2008
Sep 9;105(36):13427-32. doi: 10.1073/pnas.0805706105. Epub 2008 Sep 2. PubMed
PMID: 18765800; PubMed Central PMCID: PMC2533206.
Francipane MG, Alea MP, Lombardo Y, Todaro M, Medema JP, Stassi G. Crucial
role of interleukin-4 in the survival of colon cancer stem cells. Cancer Res.
2008 Jun 1;68(11):4022-5. doi: 10.1158/0008-5472.CAN-07-6874. Review. PubMed
PMID: 18519657.
Vermeulen L, Sprick MR, Kemper K, Stassi G, Medema JP. Cancer stem cells--old
concepts, new insights. Cell Death Differ. 2008 Jun;15(6):947-58. doi:
10.1038/cdd.2008.20. Epub 2008 Feb 15. Review. PubMed PMID: 18259194.
Todaro M, Lombardo Y, Francipane MG, Alea MP, Cammareri P, Iovino F, Di
Stefano AB, Di Bernardo C, Agrusa A, Condorelli G, Walczak H, Stassi G. Apoptosis
resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4.
Cell Death Differ. 2008 Apr;15(4):762-72. doi: 10.1038/sj.cdd.4402305. Epub 2008
Jan 18. PubMed PMID: 18202702.
2007
Garlanda C, Di Liberto D, Vecchi A, La Manna MP, Buracchi C, Caccamo N,
Salerno A, Dieli F, Mantovani A. Damping excessive inflammation and tissue damage
in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig
IL-1-related receptor, a negative regulator of IL-1/TLR signaling. J Immunol.
2007 Sep 1;179(5):3119-25. PubMed PMID: 17709526.
Dieli F, Vermijlen D, Fulfaro F, Caccamo N, Meraviglia S, Cicero G, Roberts
A, Buccheri S, D'Asaro M, Gebbia N, Salerno A, Eberl M, Hayday AC. Targeting
human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy
of hormone-refractory prostate cancer. Cancer Res. 2007 Aug 1;67(15):7450-7.
PubMed PMID: 17671215; PubMed Central PMCID: PMC3915341.
Buccheri S, Reljic R, Caccamo N, Ivanyi J, Singh M, Salerno A, Dieli F. IL-4
depletion enhances host resistance and passive IgA protection against
tuberculosis infection in BALB/c mice. Eur J Immunol. 2007 Mar;37(3):729-37.
PubMed PMID: 17304630.
Sireci G, Russo D, Dieli F, Porcelli SA, Taniguchi M, La Manna MP, Di Liberto
D, Scarpa F, Salerno A. Immunoregulatory role of Jalpha281 T cells in aged mice
developing lupus-like nephritis. Eur J Immunol. 2007 Feb;37(2):425-33. PubMed
PMID: 17273990.
Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, Iovino F, Tripodo
C, Russo A, Gulotta G, Medema JP, Stassi G. Colon cancer stem cells dictate tumor
growth and resist cell death by production of interleukin-4. Cell Stem Cell. 2007
Oct 11;1(4):389-402. doi: 10.1016/j.stem.2007.08.001. PubMed PMID: 18371377.
Siragusa M, Zerilli M, Iovino F, Francipane MG, Lombardo Y, Ricci-Vitiani L,
Di Gesù G, Todaro M, De Maria R, Stassi G. MUC1 oncoprotein promotes
refractoriness to chemotherapy in thyroid cancer cells. Cancer Res. 2007 Jun
1;67(11):5522-30. PubMed PMID: 17545635.
2006
Sireci G, La Manna MP, Di Sano C, Di Liberto D, Porcelli SA, Kronenberg M,
Dieli F, Salerno A. Pivotal advance: alpha-galactosylceramide induces protection
against lipopolysaccharide-induced shock. J Leukoc Biol. 2007 Mar;81(3):607-22.
Epub 2006 Oct 17. PubMed PMID: 17046969.
Caccamo N, Battistini L, Bonneville M, Poccia F, Fournié JJ, Meraviglia S,
Borsellino G, Kroczek RA, La Mendola C, Scotet E, Dieli F, Salerno A. CXCR5
identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and
help B cells for antibody production. J Immunol. 2006 Oct 15;177(8):5290-5.
PubMed PMID: 17015714.
Caccamo N, Sireci G, Meraviglia S, Dieli F, Ivanyi J, Salerno A. gammadelta T
cells condition dendritic cells in vivo for priming pulmonary CD8 T cell
responses against Mycobacterium tuberculosis. Eur J Immunol. 2006
Oct;36(10):2681-90. PubMed PMID: 16981183.
Caccamo N, Meraviglia S, La Mendola C, Guggino G, Dieli F, Salerno A.
Phenotypical and functional analysis of memory and effector human CD8 T cells
specific for mycobacterial antigens. J Immunol. 2006 Aug 1;177(3):1780-5. PubMed
PMID: 16849488.
Caccamo N, Dieli F, Wesch D, Jomaa H, Eberl M. Sex-specific phenotypical and
functional differences in peripheral human Vgamma9/Vdelta2 T cells. J Leukoc
Biol. 2006 Apr;79(4):663-6. Epub 2006 Feb 3. PubMed PMID: 16461739.
D'Asaro M, Dieli F, Caccamo N, Musso M, Porretto F, Salerno A. Increase of
CCR7- CD45RA+ CD8 T cells (T(EMRA)) in chronic graft-versus-host disease.
Leukemia. 2006 Mar;20(3):545-7. PubMed PMID: 16408100.
Meraviglia S, Eberl M, Vermijlen D, Todaro M, Buccheri S, Cicero G, La
Mendola C, Guggino G, D'Asaro M, Orlando V, Scarpa F, Roberts A, Caccamo N,
Stassi G, Dieli F, Hayday AC. In vivo manipulation of Vgamma9Vdelta2 T cells with
zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast
cancer patients. Clin Exp Immunol. 2010 Aug;161(2):290-7. doi:
10.1111/j.1365-2249.2010.04167.x. Epub 2010 May 10. PubMed PMID: 20491785; PubMed
Central PMCID: PMC2909411.